CRK and breast carcinoma: This is consistent with observations that loss of CrkI/II decreased the ability of ovarian cancer cells to grow within the peritoneal cavity and that ectopic expression of the microRNA miR-126, whose putative target is Crk, prevented outgrowth of gastric cancer cells in the lung and outgrowth of breast cancer cells in the lung, bone and mammary fat pad [13,38,39].