Previous studiessuggest that IL-24 selectively kills melanoma cells via an IL-20 receptor-dependentpathway that is independent of STAT3 [15].In melanoma tumor cells, IL-24 induces IFN-α, which leads to growth inhibitionand apoptosis, possibly involving FAS-FASL and TRAIL interactions [16]. This evidence concerns the gene TNFSF10 and melanoma.