Replication-competentoncolytic adenovirus SG600-IL-24 has the telomerase reverse transcriptase promoter(TERTp) and the hypoxia regulatory elements (HRE) controlling the expression ofadenoviral mutated E1a gene and the E1b, respectively [26-28].Mutation of the E1a gene and its expression driven by the telomerase promoterhinders its replication in normal cells but not in tumor cells. The gene discussed is DHTKD1; the disease is neoplasm.