HLA-C and rheumatoid arthritis: By using proliferation and cytokine assays, we determined that a peptide representing CII263-270 and containing amino acid substitutions at positions 263 (F→N) and 266 (E→D) (analog peptide A12) was profoundly suppressive, effectively attenuating arthritis in the humanized RA-mouse models, despite having very poor avidity for the MHC [6].