Overall distribution of genotypes for IL1B-511 polymorphism differed nominally between TJA patients with PJI versus those without PJI (p = 0.014, pcorr > 0.05, 2 degrees of freedom), particularly due to the overrepresentation of IL1B-511 CT heterozygotes and reciprocal decrease of CC homozygotes among PJI patients. The gene discussed is IL1B; the disease is juvenile polyposis syndrome.