APOE and Alzheimer disease: In rabbits fed 2% cholesterol for as little as eight weeks, there are as many as sixteen different indices of pathology that are similar to those seen in Alzheimer's Disease (AD) including intracellular and extracellular Aβ, breaches of the blood brain barrier, activation of microglia, apoptosis, increased levels of Apolipoprotein E, phosphorylated tau protein, changes in the cerebrovasculature, and increases in ventricular volume [1–12].