ACTA1 and Hepatic fibrosis: Male db/db mice fed a methionine/choline-deficient diet (MCD) to induce NASH and liver fibrosis and subsequently treated with a pan-caspase inhibitor, VX-166, showed a reduction in α-SMA-positive HSCs and had reduced expression of Col1a1 mRNA and reduced fibrosis, confirmed with Sirius red staining.