In a murine model of retinopathy related to prematurity, neovascularization that was induced on the vitreous side of the inner limiting membrane by hyperoxia-normoxia was absent in mice with knockdown of HIF-2α and these mice exhibited degeneration of neural layers in the retina with subsequent prolonged normoxia and a marked attenuation of EPO expression [52]. Here, EPO is linked to retinal disorder.