In fact, mutations in the FoxP3 gene (located on the X-chromosome) lead to the IPEX (immune dysfunction, polyendocrinopathy, enteropathy, X-liked) syndrome, characterized by stillbirth or food allergy, diarrhea, and several endocrine autoimmune disorders, with neonatal T1D as most prominent [204, 205]. This evidence concerns the gene FOXP3 and type 1 diabetes mellitus.