In addition, it has been reported that the Y-box binding protein-1 (YB-1), an oncogenic transcription/translation factor, which is expressed in more than 40% of breast cancers, induces the expression of CD44 and of α6 integrin, which led to enhanced self-renewal, mammosphere growth, and resistance to paclitaxel treatment [179]. The gene discussed is YBX1; the disease is breast carcinoma.