SPRR2A and hyperinsulinemic hypoglycemia, familial, 4: Prior to the HIV pandemic, BCG had a good safety record with mostly minor reactions reported and serious adverse events generally restricted to infants with primary immunodeficiency disorders including severe combined immunodeficiency (SCID), chronic granulomatous disease (CGD), DiGeorge syndrome, IFN-gamma receptor deficiency, and IL-12 deficiency [19].