SOAT1 and amyotrophic lateral sclerosis: These downregulated genes were involved in Jak-STAT signaling pathway, Cytokine-cytokine receptor interaction, Malaria, Amyotrophic lateral sclerosis (ALS), Hematopoietic cell lineage, Chagas disease, Hypertrophic cardiomyopathy (HCM), Amoebiasis, Toll-like receptor signaling pathway (Fig. 2).