The present data are in agreement with previous reports indicating the participation of CtBP1 in E-cadherin repression [48] and the description of Snail2/CtBP1/HDAC1 complexes in Snail2 repression of several target genes, such as BRCA2, VDR and UbcH5c, in breast cancer cells [36]–[38], and provide additional information on the SLUG domain. This evidence concerns the gene SNAI2 and breast cancer.