In addition, knockdown of FLJ20420 expression also significantly increased the expression of PRKCBP2, TGFBR1, TGFB2, CLCN4, TRAF3, MYLK and ACTA2, while decreasing the expression of SMAD5 and prot-LBC, resulting in an increased apoptotic potential in FLJ20420-silenced lung cancer cells. This evidence concerns the gene SMAD5 and lung cancer.