Autosomal genes (GATAD1, SCLA12, PDE6B) involved in the metabolism of cyclic nucleotides, glucose transport and neurohumoral stimulation were identified in women with heart failure, unlike the male population with heart failure, where the genes responsible for arrhythmias, self immunity and cellular homeostasis (KCNK1, CD24, PLEKHA8) were overexpressed [1] (Table 1). Here, PLEKHA8 is linked to heart failure.