MMP9 and Hernia: Although there is no association between the hyper–algic form of hernia and histo–pathological modification of the MMP–9 positive type, following a more profound analysis of many health state parameters, our study shows that the average EQ–5D pre–urgery score of the MMP–9 positive subjects is 0.4969, in comparison to 0.5623 for the MMP–9 negative ones (X2=9), therefore, we can establish that the modification in the extracellular disk matrix, significantly affects the patient's pre–surgery quality of life, both statistically and clinically (Table 2).