The treatments for HE typically include (1) elimination or correction of the underlying factors participating in HE, (2) restoring metabolic homeostasis, (3) promoting regeneration of liver cells, (4) antibiotic agents that inhibit mucosal glutaminase in the intestine to reduce ammonia production in the gut, and (5) artificial liver support or liver transplantation [22–26]. Here, GLS is linked to hereditary elliptocytosis.