Some of the other up-regulated transcripts in the VMB include members of axon guidance signaling (Rock1, Adam22), zinc finger proteins (Eif2c3 and novel KRAB box and zinc finger, C2H2 type domain containing protein) and one of the candidate genes for late onset Alzheimer's Disease (Plce1) [24]. The gene discussed is PLCE1; the disease is Alzheimer disease.