Besides differences in the response of epithelial versus hematological cells towards overexpression or knockdown of DNMT3B these data also indicate that murine hematological tumor model as well as developmental models [35], [36] have a higher level of plasticity with regard to alterations of DNA methylation than established cancer cells in vitro such as the HCT-116 colon cancer cells analyzed in our siRNA and shRNA knockdown studies. This evidence concerns the gene DNMT3B and colonic neoplasm.