The results showed increased expression of DNMT3B in a subset of colon cancer cell lines, whereas normal human fibroblast WI-38 cells and human non-tumorigenic hTERT-immortalized mammary epithelial cells with reduced levels of p53 (HMEC-T53) showed only a very weak expression on the mRNA level and no detectable signal in immunoblots (Figure 1B, C). The gene discussed is DNMT3B; the disease is malignant colon neoplasm.