In a case-control GWA study in Spain of 476 schizophrenia patients and 447 control subjects, and then further corroborated in a second sample comprising 4,069 cases and 15,128 control subjects of European origin, a different highly significant nonsynonymous SNP within the SLC39A8 gene was described; the allelic frequency of this missense mutation is 0.34 in Europeans [43]. Here, SLC39A8 is linked to schizophrenia.