Using the Haploview program and genotypes in the 63 280 kb to 63 560 kb region from individuals with European ancestry from the HapMap project, we saw that rs356570 tags for 71 SNPs located further upstream of HTR1A. A number of these SNPs are located within or around the RNF180 gene, suggesting that this gene could be involved in T1D susceptibility as well. Here, RNF180 is linked to type 1 diabetes mellitus.