KNG1 and preeclampsia: Moreover, differences exist between BK- and ACh- induced relaxation of the mesenteric arteries from spontaneously hypertensive rats at different ages, suggesting a more detrimental effect of increased blood pressure on BK-induced vasorelaxation [22], while selective impairement of endothelium-dependent relaxation to ACh but not BK is observed in isolated small omental arteries from women with preeclampsia [23].