Most striking is the novel observation that decreased expression of EZH2 results in constitutive expression of CIITApIV and HLA-DRA transcripts in unstimulated tumor cells; these results provide increased evidence for EZH2 as a target for anti-tumor immunotherapies and provide additional mechanistic links to roles for EZH2 in tumor cell metastasis. The gene discussed is EZH2; the disease is neoplasm.