Multivariate regression analysis found that the occurrence of major cardiovascular events was associated with a high level of CD62E+ microparticles (HR, 3.73; 95% CI, 1.39 to 10.07; P = 0.009), advanced age (HR, 3.36; 95% CI, 1.25 to 10.36; P = 0.018), coronary artery disease (HR, 4.70; 95% CI, 1.06 to 20.92; P = 0.042), and the use of anticoagulants (HR, 10.23; 95% CI, 1.56 to 66.92; P = 0.015). The gene discussed is SELE; the disease is coronary artery disorder.