Some studies have revealed that TLR proteins utilize a similar signaling cascade that ultimately culminates in the activation of NF-κB, activator protein-1, phosphatidylinositol 3-kinase, and mitogen-activated protein (MAP) kinases which play a critical role in pulmonary infectious disease, inflammation and allergic asthma [7], [8]. The gene discussed is NFKB1; the disease is allergic asthma.