Analysis of Foxp3-stained lung sections from S. pneumoniae-infected PBS-treated and P17-treated mice confirmed that P17 treatment substantially reduced numbers of Foxp3+ cells in the lungs of infected BALB/c mice at both 24 and 48 hours p.i., which correlated with development of sepsis in these mice (Figure 5 D). The gene discussed is FOXP3; the disease is Sepsis.