Exposure of Jurkat T cells and lung cancer cell lines to BaP resulted in hypermethylation of a CGI in region 1 and specific non-CGI CpG sites in region 2 of the IFNγ promoter and reduced IFNγ expression, but these changes were significant only in cells treated with low doses (0.1 and 1 nM) of BaP. Here, IFNG is linked to lung carcinoma.