NCOA4 and Familial prostate cancer: Li et al. [90] and Ligr et al. [32] reported decreased NcoA4 mRNA expression in both prostate intraepithelial neoplasia, a recognized precursor lesion for prostate cancer, and malignant prostate relative to benign prostate, whereas Mestayer et al. [87] reported similar levels in both normal and malignant prostate.