Radicioni et al [13] characterized the hormonal profiles of 24 pubertal PWS males based on LH, FSH, inhibin B and testosterone to hypogonadotropic hypogonadism of central origin for LH (with low secretion of testosterone) and/or FSH(with low secretion of inhibin B), early primary testicular dysfunction secondary to Sertoli cells damage (elevated FSH and low inhibin B) and a combined form of hypogonadism . Here, PLOD1 is linked to hypogonadism.