Because the EGFR, as well as many of its downstream effectors, can have oncogenic properties in humans [5], our findings that RAB-7 antagonizes LET-23 EGFR signaling, suggest the possibility of Rab7 having tumor suppressor activities in humans like that of c-Cbl through promoting downregulation of activated RTKs. The gene discussed is EGFR; the disease is neoplasm.