Because astrocytes express both metabotropic glutamate and AMPA receptors, which upon activation result in erbB receptor-mediated glia-to-neuron signaling events [43], [44], it is possible that a defect in astroglial SynCAM1 function results in ADHD-like behaviors because of an alteration in excitatory glia-to-neuron communication. This evidence concerns the gene CADM1 and attention deficit-hyperactivity disorder.