PRNP and Creutzfeldt Jacob disease: Although the interpretation and relevance of these data for CJD classification and strain-typing was contested [26], [49], by showing that such PrPSc-selective antibodies recognize PrP fragments that do not match the physicochemical properties of those detected with standard PrPSc typing, an issue that was also discussed in the latter of these studies [50], these results are of interest and further investigations are required to unravel the biological basis of co-occurrence of PrP types.