Intrarenal synthesis of angiotensin II [5], [6], promoted by elevated renin and pro-renin receptor expression [7], contributes to the pathology of hypertension in the cyp1a1-Ren2 rat, and the model is therefore complementary to approaches using chronic infusion of angiotensin II, in which renin activity is suppressed. The gene discussed is AGT; the disease is Hypertension.