PPOX and benign prostatic hyperplasia: Based on the results that OsCOI1 is responsive to LF infestation and MeJA, and that COI1 silencing in rice increases susceptibility to chewing insects and impairs the inducibility of TrypPI, PPO and POD, we conclude that the JA signal transduction pathway plays a key role in rice defense against chewing insects, and COI1 is specifically required for the regulation of JA-mediated insect defense in response to the chewing insect LF, but not for SA-mediated defense in response to BPH.