Many mediators, including transformation growth factor-beta1 (TGF-beta1), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF), are also upregulated in glomeruli and tubules and are believed to be involved in the progression of glomerular sclerosis and tubulointerstitial fibrosis [24], [25], [26]. This evidence concerns the gene EGF and Glomerular sclerosis.