Matsuda K et al. [23] found that EGF promotes proliferation via p38 MAPK signaling cascades in ASPC-1, PANC-1 and T3M4 pancreatic cancer cell lines, and p38 MAPK inhibitor SB203580 can inhibit EGF-stimulated mitogenesis. The gene discussed is EGF; the disease is familial pancreatic carcinoma.