FOS and familial expansile osteolysis: We also assert that there is no conceivable reason why either upstream effectors (as there is no food, peripheral or other cues expected/presented at this timepoint) nor downstream affectors (which are reset to normal, SCN driven, light/activity/food consumption/body temperature rhythms for appropriate control of behaviour and physiology under ad libitum conditions) should be influencing the levels of c-FOS expression in regions not critically involved in the timekeeping mechanism of the FEO.