We found that compared with controls CC10 expression levels was significantly down-regulated in CRS (control vs. CRS, 22.29±7.97 ng/mL vs. 7.12±2.62 ng/mL, P<0.01), whereas the IL-1β induced IL-8 expression was significantly enhanced in CRS (control vs. CRS, 6.37±2.11 ng/mL vs. 13.29±2.38 ng/mL, P<0.01). The gene discussed is IL1B; the disease is congenital rubella syndrome.