ANGPT1 and Myocardial fibrosis: However, treatment with Ad-Ang-1 has little effect on the number of TUNEL/SMA positive cells (Figure 4E). Compared to db/db mice treated with Ad-β-gal, mice treated with Ad-Ang-1 showed a significant decrease in the area of myocardial fibrosis at 14 days after MI (Figure 4F).