To test whether the WNT/β-catenin activation occurs with FGFR2 and FGFR3 harboring pathogenic mutations, we used 6 activating FGFR3 mutants (N540K, G380R, R248C, Y373C, K650M, K650E), and 5 activating FGFR2 mutants (S252W, P253R, C342R, C342Y, Y375C), known to be associated with human skeletal dysplasias, cranial malformations, skin, and cancer [10], [11]. The gene discussed is FGFR2; the disease is cancer.