Synaptophysin staining was also quantified in the primary motor, somatosensory and parietal areas of the cerebral cortex, but no significant differences were observed between WT and MPS brains at either time point (Figure 8C), suggesting that the altered VAMP2 staining represents a rearrangement of the pre-synaptic compartment rather than an overt loss of synapses. The gene discussed is VAMP2; the disease is mucopolysaccharidosis.