Alzheimer's disease (AD) is characterized by both amyloid-β (Aβ) plaques and tau tangles in the brain while tau pathology in the absence of plaques occurs in a subset of frontotemporal lobar degeneration (FTLD-Tau) that includes FTDP-17 and Pick's disease (PiD) [1]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.