To determine the effects of pathological tau on SFPQ directly, we stably expressed both wild-type and P301L human tau in human SH-SY5Y neuroblastoma cells, a cell culture model of tau pathology [33], followed by either mitomycin C (Mito C)-mediated cell cycle arrest or neuronal differentiation with retinoic acid (RA). This evidence concerns the gene MAPT and neuroblastoma.