Our subsequent analysis for the first time revealed a nucleo-cytoplasmic redistribution of SFPQ under pathological conditions, similar to what has been reported for TDP-43 that forms cytoplasmic aggregates in amytrophic lateral sclerosis (ALS) and FTLD-TDP [9], and FUS in ALS [10], [11] and FTLD-FUS [12]. Here, TARDBP is linked to amyotrophic lateral sclerosis.