AGTR2 and cardiac hypertrophy: We performed a series of in vivo studies, including wild type mice with control pellet, wild type mice with Ang II infusion, wild type mice with Ang II plus hydralazine, wild type mice with Ang II plus PD123319 and AT2 knockout mice with Ang II (Figure 4, A,B,C,D) to distinguish the functional roles of AT2 and pressure load in cardiac hypertrophy.