The cumulative risk of developing islet autoantibodies by age 10 years was 7% (95% CI: 5–9%) in children carrying the TCF7L2 CT or TCF7L2 CC genotype compared to 12% (95% CI: 10–14%) in children carrying the type 2 diabetes protective TCF7L2 TT genotype (P = 0.015; Pcorrected = 0.18) (Figure 1). The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.