Copy number analysis was performed on genes from two well established AMD associated genomic loci, targeting seven genes on chromosome 1q32 (CFH, CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, F13B) and two genes on chromosome 10q26 (ARMS2 and HTRA1) (Figure 1). The gene discussed is HTRA1; the disease is age-related macular degeneration.