On the basis of the genomic architecture of the RCA block and the as yet unexplored chromosome 10 regions for CNV, we hypothesized that, in addition to the common CFHR3-1 deletion, other potential rearrangements encompassing the CFH, CFHR4, CFHR2, CFHR5, F13B, ARMS2 and HTRA1 genes may contribute to AMD pathogenesis. Here, ARMS2 is linked to age-related macular degeneration.