TNFSF10 and neoplasm: In Fig. 6A it is possible to note that Topotecan exerts a marked pro-apoptotic effect when added in combination with LBW242 and TRAIL in A2780WT PINCO cells; the cell death of tumor cells caused by these agents when used in combination is greatly inhibited by the pan-caspase inhibitor zVAD-fmk and therefore is mainly mediated through caspase activation.