In a previous study, Reichlin et al showed that the positive predictive value of hs-cTnT in diagnosing acute myocardial infarction was only 19% (cut-off 2 pg/mL, limit of detection) or 50% (cut-off 14 pg/mL, 99th percentile of healthy reference population), while the negative predictive value was nearly perfect (99–100%, dependent on cut-off) [5]. This evidence concerns the gene TNNT2 and acute myocardial infarction.