There are no results reported on optimal delta cut-offs considering a longer follow-up period of years apart from the study of deFilippi et al, who recently showed that for an increase in hs-cTnT concentrations >50% over two to three years, the risk for heart failure and cardiovascular death were 1.7 and 1.8-fold, respectively [11]. The gene discussed is TNNT2; the disease is heart failure.