Also, during acute murine brucellosis antigen presenting cells could process intact Brucella and present the NV9 peptide to CD8+ T cells generating a robust cytotoxic T cell response [16]; however, in the presence of the Brucella TcpB protein cytotoxicity is inhibited and as infection progressed cytokine production by CD8+ T cells is reduced. This evidence concerns the gene CD8A and brucellosis.