TP53 and breast cancer: The study highlights several important points: 1) JKA97 significantly inhibits breast cancer cell growth; 2) JKA97 induces cell apoptosis; 3) inhibition of cell proliferation and cell cycle progression appear to be major mechanism by which JKA97 exerts its anti-cancer effects; 4) JKA97 up-regulates p21 expression at the transcriptional level, rather than post-transcriptional level, independent of p53; and 5) JKA97 decreases the growth of human breast cancer xenograft tumors in mice, in a dose-dependent manner.