TP53 and breast cancer: Three human breast cancer cell lines representing three different genetic backgrounds (MCF7/p53 wild-type; MCF7/p53 knockdown, and MDA-MB-468/p53 mutant) were exposed to various concentrations of the test compound (0, 1, 2.5, 5, 10, 25, and 50 μM) for 72 hrs, and cell survival percentages were determined.