While much work remains to be done, the coherence of the overall pattern of findings that confirmed the a priori hypothesized biological changes and mechanisms: i.e., increased tumor burden, decreased chemokine, cytokine, and cellular indices of protective immunity, increased Treg-mediated suppression/tolerization of anti-tumor immunity, and increased corticosterone and VEGF levels, in HiAnx compared to LoAnx mice, and agreement with the literature regarding the effects of chronic stress on cancer [25], [26], also speaks to the usefulness and relevance of the approach used here. This evidence concerns the gene VEGFA and neoplasm.