Importantly, the coherence of the overall pattern of findings that confirmed the a priori hypothesized biological changes and mechanisms: i.e., increased tumor burden, decreased chemokine, cytokine, and cellular indices of protective immunity, and increased corticosterone and VEGF levels, in HiAnx compared to LoAnx mice, and agreement with the literature regarding the effects of chronic stress on cancer [25], [26], suggests that the observed results were not random or due to false positive findings. The gene discussed is VEGFA; the disease is neoplasm.