Elevated levels of the three markers (cut-off for CA 125 = 66 U/ml; CA 15-3 = 25 U/ml; CEA = 4.2 U/ml) had a sensitivity of 69% and specificity of 88% for the prediction of pericardial effusions caused by malignancies. The gene discussed is CEACAM5; the disease is pericardial effusion.